The acidity of the urine modulates bladder function
The epithelial cells of bladder or urothelial cells may release neurotransmitters and mediators such as adenosine triphosphate (ATP) in response to chemical or mechanical stimuli. Thus, distension of urothelial cells during bladder filling stimulates cells and induces release of ATP that signals the need to urinate. Biologists at the University of Sydney have shown that the acidity of urine is a major stimulant of urothelial cells. The study was to compare the release of ATP by the mucosa of the rat bladder (epithelium and lamina propria) in response to different stimuli: acidity (pH 6,6-5), capsaicin, electrical stimulus and distension (150 %). The response generated by the acid is by far the most important and increases with
decreasing pH. The response to acid appears to involve two types of receptors, the vanilloid receptor TRPV1 and ASICS (Acid-Sensing Ion Channel). Ion channel sensors acid (ASICs) are activated by an increase in extracellular acidity that occurs during conditions of acute or chronic pain, for example.
The treatment of overactive bladder using substances that reduce the activity of neurotransmitter receptors in the bladder wall. The study results suggest new therapeutic approaches for the treatment of overactive bladder. ASICs receptors could be considered potential targets for developing drugs for this condition currently treated with substances that reduce the activity of neurotransmitter receptors in the bladder wall.
The treatment of overactive bladder using substances that reduce the activity of neurotransmitter receptors in the bladder wall. The study results suggest new therapeutic approaches for the treatment of overactive bladder. ASICs receptors could be considered potential targets for developing drugs for this condition currently treated with substances that reduce the activity of neurotransmitter receptors in the bladder wall.
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