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A family of blood plasma proteins that is necessary for the blood-clotting process. This group includes factor VIII, which in most cases of hemophilia, is found to be deficient. When the skin surrounding a body is cut or otherwise disrupted a cascade of these antihemophilic factors, or "clotting factors," are initiated near the problem site. Certain clotting factors cause platelets in the blood to become "sticky" which attach to the wounded site and, in turn block the exit of blood from the body. The clotting factors also induce the binding of fibrin molecules to create an insoluble meshwork clot preventing blood loss.


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